A direct one-pot conversion of (substituted) styrene(s) into the corresponding (substituted) (R)-phenylethan-1-ol(s) in a highly enantioselective manner has been achieved by using a “chemoenzymatic catalytic system”, comprising a palladium-catalyzed Wacker–Tsuji oxidation and subsequent enantioselective enzymatic reduction of the in situ formed (substituted) acetophenone(s) (see scheme).
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Schnapperelle et al. (2011) studied this question.
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