High-Dosage Vitamin E Supplementation and All-Cause Mortality

Letters19 July 2005High-Dosage Vitamin E Supplementation and All-Cause MortalitySimin Nikbin Meydani, DVM, PhD, Joseph Lau, MD, Gerard E. Dallal, PhD, and Mohsen Meydani, DVM, PhDSimin Nikbin Meydani, DVM, PhDFrom Tufts University, Boston, MA 02111.Search for more papers by this author, Joseph Lau, MDFrom Tufts University, Boston, MA 02111.Search for more papers by this author, Gerard E. Dallal, PhDFrom Tufts University, Boston, MA 02111.Search for more papers by this author, and Mohsen Meydani, DVM, PhDFrom Tufts University, Boston, MA 02111.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-2-200507190-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Miller and colleagues (1) reported that supplemental intake of vitamin E at dosages greater than 150 IU/d progressively increases all-cause mortality. There are several problems with their analysis and interpretation of the data. The harmful effect above 150 IU/d is an artifact of the model they chose to fit. When researchers fit a quadratic-linear spline, the result must be a quadratic-linear spline regardless of whether the data behave that way. In another reasonable model, the favorable response to vitamin E is constant until a certain dose, above which the change in all-cause mortality risk difference is linear. ...References1. Miller ER, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med. 2005;142:37-46. [PMID: 15537682] LinkGoogle Scholar2. Meydani SN, Leka LS, Fine BC, Dallal GE, Keusch GT, Singh MF, et al. Vitamin E and respiratory tract infections in elderly nursing home residents: a randomized, controlled trial. JAMA. 2004;292:828-36. [PMID: 15315997] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Tufts University, Boston, MA 02111.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMeta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality Edgar R. Miller III , Roberto Pastor-Barriuso , Darshan Dalal , Rudolph A. Riemersma , Lawrence J. Appel , and Eliseo Guallar High-Dosage Vitamin E Supplementation and All-Cause Mortality Kent J. DeZee , William Shimeall , Kevin Douglas , and Jeffrey L. Jackson High-Dosage Vitamin E Supplementation and All-Cause Mortality Antonio M. Possolo High-Dosage Vitamin E Supplementation and All-Cause Mortality Ishwarlal Jialal and Sridevi Devaraj High-Dosage Vitamin E Supplementation and All-Cause Mortality Thomas Carter High-Dosage Vitamin E Supplementation and All-Cause Mortality Joseph E. Baggott High-Dosage Vitamin E Supplementation and All-Cause Mortality Edgar R. Miller III , Lawrence J. Appel , Eliseo Guallar , and Roberto Pastor-Barriuso Brief Communication: The Prevalence of High Intake of Vitamin E from the Use of Supplements among U.S. Adults Earl S. Ford , Umed A. Ajani , and Ali H. Mokdad An Editorial Update: Annus horribilis for Vitamin E Eliseo Guallar , Daniel F. Hanley , and Edgar R. Miller III High-Dosage Vitamin E Supplementation and All-Cause Mortality David H. Blatt and William A. Pryor High-Dosage Vitamin E Supplementation and All-Cause Mortality Koyamangalath Krishnan , Sharon Campbell , and William L. Stone High-Dosage Vitamin E Supplementation and All-Cause Mortality Harri Hemilä High-Dosage Vitamin E Supplementation and All-Cause Mortality Wee-Shiong Lim , Rajka Liscic , Chengjie Xiong , and John C. Morris High-Dosage Vitamin E Supplementation and All-Cause Mortality Connie Marras , Anthony E. Lang , David Oakes , Michael P. 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Tanner , and Stanley Fahn Metrics Cited ByVitamin E for the treatment of E-antigen-positive chronic hepatitis B in paediatric patients: results of a randomized phase 2 controlled studyVitamin E for the treatment of children with hepatitis B e antigen-positive chronic hepatitis: A systematic review and meta-analysisα-Tocopherol supplementation reduces 5-nitro-γ-tocopherol accumulation by decreasing γ-tocopherol in young adult smokersPossible role of tocopherols in the modulation of host microRNA with potential antiviral activity in patients with hepatitis B virus-related persistent infection: a systematic reviewAntioxidants in Food: Mere Myth or Magic Medicine?Nutrient plasma levels achieved during treatment that reduces noise-induced hearing lossBioactive Nutritional Supplements for Chronic Kidney Disease: Potential Cost BenefitsNo evidence supports vitamin E indiscriminate supplementationAntioxidants and Modulation of Cardiovascular DiseaseAdverse effects of vitamin E by induction of drug metabolismCellular, molecular and clinical aspects of vitamin E on atherosclerosis preventionVitamin E Regulatory MechanismsThe Roles of α‐Vitamin E and Its Analogues in Prostate Cancer 19 July 2005Volume 143, Issue 2Page: 153KeywordsAge groupsCardiovascular diseasesConflicts of interestNursing homesPrevention, policy, and public healthUpper respiratory tract infectionsVitamin E ePublished: 19 July 2005 Issue Published: 19 July 2005 CopyrightCopyright © 2005 by American College of Physicians. 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