Synthesis and antibacterial activity of some novel sebacic acid derivatives

Diverse biological activities, including antibacterial effects have been reported for sebacic acid and alkyl esters of amino acids.New derivatives of sebacic acid were synthesized in a one pot approach by the formation of amide bond between hydroxyl group of the sebacic acid and amine group of different amino acid alkyl ester hydrochloride salts.The mean synthesis yield for the studied compounds was ~58%.The structures of the newly synthesized compounds were confirmed by inspection of their 1 H-NMR, 13 C-NMR, IR and elemental analysis.The new compounds were screened for antimicrobial activities against six common strains of Gram-negative and Grampositive bacteria.The results of the present work show low to moderate antibacterial activity for the studied compounds.