Whole-exome sequencing reveals germline-mutated small cell lung cancer subtype with favorable response to DNA repair–targeted therapies

Camille Tlemsani; Nobuyuki Takahashi; Lőrinc Sándor Pongor; Vinodh N. Rajapakse; Manoj G Tyagi; Xinyu Wen; Grace‐Ann Fasaye; Keith Thomas Schmidt; Parth Anil Desai; Chul Kim; Arun Kumar Rajan; Shannon Swift; Linda C. Sciuto; Rasa J Vilimas; Santhana Webb; Samantha Nichols; William Douglas Figg; Yves G. Pommier; Seth M. Steinberg; Jun Stephen Wei; Udayan Guha; Clesson Turner; Javed Iqbal Khan; Anish Thomas

doi:10.1126/scitranslmed.abc7488

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Abstract

), a homologous recombination-related gene, using agents synthetically lethal with homologous recombination deficiency, resulted in a notable disease response. This work demonstrates that SCLC, currently thought to result almost exclusively from tobacco exposure, may have an inherited predisposition and lays the groundwork for targeted therapies based on the genes involved.

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Tlemsani et al. (2021) studied this question.

synapsesocial.com/papers/6ab6041e4dfd64f4ba5647bb https://doi.org/10.1126/scitranslmed.abc7488

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Whole-exome sequencing reveals germline-mutated small cell lung cancer subtype with favorable response to DNA repair–targeted therapies

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Abstract

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Whole-exome sequencing reveals germline-mutated small cell lung cancer subtype with favorable response to DNA repair–targeted therapies

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Abstract

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