Summary The kinetics of the initial step of killing of sensitive bacteria by colicin CA42‐E2 suggest that only one lethal unit or molecule is required to kill. Using a new sensitive assay it is shown that 30‐90 such lethal units can be adsorbed on one cell. Each lethal unit corresponds to 105 Dalton in the purified colicin which is similar to the probable molecular weight. The significance of these findings is discussed.
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PR Reeves (1965) studied this question.