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Hemoglobin F and A synthesis was studied in in vitro suspensions of normal adult human bone marrow. Hb A synthesis continued throughout the 7 2-hour period whereas Hb F synthesis ceased after 24 hours. Erythropoietin, added in vitro, stimulated total hemoglobin synthesis without affecting Hb F synthesis. Hypoxia depressed total globin synthesis without affecting Hb F synthesis. Thus the synthesis of Hb A and F appears to respond independently to environmental stimuli.
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Necheles et al. (1965) studied this question.
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