The article highlighted in this issue is “A Statistical Evaluation of Toxicity Study Designs for the Estimation of the Benchmark Dose in Continuous Endpoints,” by W. Slob, M. Moerbeek, E. Rauniomaa, and A. H. Piersma (pp. 167–185).
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Lorenz R. Rhomberg (2005) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: