Review demonstrates phosphorus-based nucleic acid visualization in cells and viruses, highlighting analytical electron microscopy for nanoscale elemental mapping.
Analytical electron microscopy techniques, including energy-dispersive X-ray spectroscopy (EDX) and electron energy-loss spectroscopy (EELS), are employed in materials science and biology to visualize and chemically map diverse elements. This review presents cases of successful identification of nucleic acids in cells and in DNA- and RNA-containing viruses that use the chemical element phosphorus as a marker.
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Sokolova et al. (2024) studied this question.
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