Chromosomal abnormalities in isolated persistent left superior vena cava: A systematic review and meta-analysis

=29.0%, p=0.15). Sensitivity analyses demonstrated the robustness of the findings. Although the risk of chromosomal abnormalities in sonographically isolated PLSVC is low, it is not negligible. Therefore, isolated PLSVC should not be considered an indication for routine invasive prenatal diagnosis, and clinical decision-making should be individualized based on maternal age, serum screening or cell-free DNA results, nuchal translucency findings, detailed fetal anatomical assessment, and patient preference.