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Experimental study demonstrates efficient asymmetric allylic alkylation of benzyl trifluoromethyl sulfides using chiral Lewis bases, suggesting a powerful route to chiral fluorinated motifs.
A series of benzyl trifluoromethyl sulfides bearing a nitro group were utilized as CF3S-containing building blocks to construct chiral CF3S-containing molecules via organocatalytic asymmetric allylic alkylation. In such reactions, good to high yields (up to 87%) and excellent stereoselectivity (up to 99% ee, >20:1 dr) were obtained using chiral Lewis base catalysts.
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Wu et al. (2026) studied this question.
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