The stereoselective total synthesis of the cyclodepsipeptide nodupetide (1) with a 3-hydroxy-4-methylhexanoic acid (HMHA) moiety is described. Evan’s aldol approach for fixing the chirality in the HMHA motif and classical liquid-phase peptide coupling procedures for construction of the tetrapeptide were utilized. Preliminary biological evaluation of the synthesized natural product along with its two acyclic precursors indicated cytotoxic activities.
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Paipuri et al. (2026) studied this question.
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