Segmental thickening of the proximal duodenum was found in a 3%-month-old female guinea pig, one of 140 obtained from a commercial source (Small Stock Industries, Pea Ridge, Ark.) at 2 weeks of age and used in a 90-day study. The guinea pig had shown no clinical signs of gastrointestinal disease, and significant gross and microscopic lesions were limited to the duodenum. Beginning at its junction with the stomach, the wall of the proximal duodenum was thickened in its entire circumference for a distance of 3.5 centimeters, then abruptly
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Elwell et al. (1981) studied this question.
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