Key result
Pulmonary hypertension secondary to left heart disease was associated with a significantly higher magnitude of wave reflection (Sy/x 31.0% vs 17.5%) compared to controls, without a significant increase in pulse wave velocity.
Why the study?
The characteristics of the pulmonary trunk and pulmonary arterial properties in pulmonary hypertension secondary to left heart disease (PH-LHD) were not well characterized using pressure-velocity loops.
Can Pressure-Velocity Loops (PU-Loops) characterize differences in pulmonary arterial properties and stiffness in patients with pulmonary hypertension secondary to left heart disease compared to controls and ASD?
Observational (n=24)
Can Pressure-Velocity Loops (PU-Loops) characterize differences in pulmonary arterial properties and stiffness in patients with pulmonary hypertension secondary to left heart disease compared to controls and ASD?
PU-loops demonstrate that pulmonary arteries in PH-LHD undergo remodeling to maintain stable arterial stiffness despite chronic pressure elevation, offering a simple clinical assessment method.
: 1) The magnitude of wave reflection was elevated in PH-LHD significantly as compared with control and ASD. 2) Despite the significant increase in PA-PWV caused by abrupt elevation in Pm during VM in control, chronic elevation in Pm did not increase PA-PWV in PH-LHD significantly. It was hypothesized that the PA constituted a self-regulating system for maintaining the arterial stiffness stable against the chronic elevation in Pm in PH-LHD by a remodeling of increasing proximal pulmonary arterial crosssectional area gradually, which was compatible with the Moens-Korteweg equation. The PU-loop could provide a new simple and conventional method for assessing the pulmonary arterial properties, clinically. (This is a translation of J Jpn Coll Angiol 2016; 56: 45-53.).
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Hanya et al. (2017) conducted an observational in Pulmonary hypertension secondary to left heart disease (n=24). Pulmonary hypertension secondary to left heart disease vs. Normal cardiopulmonary function was evaluated on Magnitude of reflected wave (Sy/x) (p=0.009). Pulmonary hypertension secondary to left heart disease was associated with a significantly higher magnitude of wave reflection (Sy/x 31.0% vs 17.5%) compared to controls, without a significant increase in pulse wave velocity.
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