Synthesis of α-Ketothioamides via Willgerodt-Kindler Reaction of Arylglyoxals with Amines and Sulfur under Solvent-Free Conditions

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Willgerodt–Kindler reaction of arylglyoxal hydrates with secondary amines and elemental sulfur under solvent-free conditions at 80 °C is developed, in which α-ketothioamides are obtained in 70–90% yield in 0.6–1 hour. The X-ray crystal-structure analysis for one compound was obtained.