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A new two-step approach for the synthesis of 6 H -indolo[2,3- b ]quinolines is described using indole C3 alkylation and a one-pot reduction–cyclization–aromatization sequence. The synthesis of the parent 6 H -indolo[2,3- b ]quinoline system constitutes a formal synthesis of the alkaloid neocryptolepine (cryptotackieine).
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Tilve et al. (2012) studied this question.
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