The effects were examined of Sho-seiryu-to and Ryo-kan-mi-shin-ge-nin-to on the degranulation, expression of adhesion molecules and viability of human eosinophils. Eosinophil degranulation by granulocyte/macrophage-colony stimulating factor (GM-CSF) and platelet activating factor (PAF) was significantly inhibited in a dose dependent fashion by Sho-seiryu-to and Ryo-kan-kyo-mi-shin-ge-nin-to. Mean fluorescence intensity (MFI) of constitutively expressed CD11b/CD18 on eosinophils was augmented by GM-CSF or PAF stimulation; however, the increased CD11b/CD18 expression on eosinophils was significantly down-regulated by Sho-seiryu-to. Eosinophil survival in the presence of recombinant human interleukin-5 in vitro was significantly inhibited by 1000 μg/mL of Sho-seiryu-to and Ryo-kan-kyo-mi-shin-ge-nin-to, which possess an inhibitory effect on eosinophil function, suggesting their usefulness in the treatment of allergic diseases.
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Okubo et al. (1997) studied this question.