Key result
Anxiety symptoms, but not depression symptoms, correlated with higher propofol requirements for sedation at MOAA/S 3 (r=0.249, P=0.008) and MOAA/S 1 (r=0.190, P=0.045) in females.
Why the study?
Do anxiety or depression symptoms increase propofol requirements for sedation in female patients undergoing hysteroscopic surgery?
Cohort
Do anxiety or depression symptoms increase propofol requirements for sedation in female patients undergoing hysteroscopic surgery?
Female patients with anxiety symptoms require higher doses of propofol for sedation during hysteroscopy, whereas depression symptoms do not affect propofol requirements.
Anxiety may influence propofol dosing needs during hysteroscopic sedation; hypothesis-generating and warrants prospective confirmation.
Mental disorders are thought to affect various clinical outcomes during the perioperative period. Among them, anxiety and depression are 2 of the most common types. However, the impacts of anxiety or depression on propofol requirements remain unclear. This study aimed to investigate the effects of anxiety or depression symptoms on the propofol requirements for sedation in females. This study recruited female patients aged 18 to 65 years, with American Society of Anesthesiologists physical status classification of 1 to 2, who were scheduled for hysteroscopic surgery under propofol-based intravenous anesthesia. The day before surgery, the Hospital Anxiety and Depression Scale (HADS) was used to assess the symptoms of anxiety and depression within the past 6 months. Target-controlled propofol was gradually titrated to achieve 3 desired levels of sedation: Modified Observer's Assessment of Alertness/Sedation scale (MOAA/S) score 3, MOAA/S score 1, and MOAA/S score 1 and Narcotrend Index <65. The effect-site concentration of propofol correlated with HADS-Anxiety scores for the sedation levels of MOAA/S 3 and 1 (r = .249, P = .008; and r = .190, P = .045, respectively). However, the propofol requirements did not correlate with HADS-Depression scores at any sedation level. In conclusion, female patients with anxiety symptoms, but not depression symptoms, required a higher dose of propofol for sedation in hysteroscopy.
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Li et al. (2020) conducted a cohort in Scheduled for hysteroscopic surgery. Anxiety or depression symptoms was evaluated on Propofol requirements for sedation (effect-site concentration) (r = 0.249, p=0.008). Anxiety symptoms, but not depression symptoms, correlated with higher propofol requirements for sedation at MOAA/S 3 (r=0.249, P=0.008) and MOAA/S 1 (r=0.190, P=0.045) in females.
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