Key result
Higher whole blood viscosity links to an increased burden of multiple cardiovascular risk factors.
Why the study?
Blood viscosity is a determinant of vascular resistance and is expected to contribute to blood pressure, but its association with cardiovascular risk factors in hypertensive patients at high altitude is not well established.
Cross-Sectional (n=132)
No
In hypertensive patients living at high altitude, increased whole blood viscosity is associated with worse renal and lipid profiles.
Answers are grounded in this paper and cite their sources.
High blood viscosity was associated with worse renal and lipid profiles in high-altitude hypertensives; hypothesis-generating and leaves open causality or intervention targets.
Background Blood viscosity is a determinant of vascular resistance, and it is expected to contribute to blood pressure. Arterial hypertension (HTN), in addition to other cardiovascular risk factors, contribute to cardiac morbidity. Our study aimed to establish the association between cardiovascular risk factors including HTN and whole blood viscosity in Ecuadorian patients. Material and methods We studied 132 patients with the diagnosis of HTN. Fifteen cardiovascular risk factors were analyzed. The association between whole blood viscosity (WBV) and the number of cardiovascular risk factors was studied. The association between blood viscosity and risk factors was analyzed. Results One hundred and thirty-two patients were analyzed. Blood viscosity was associated with a number of cardiovascular risk factors. Creatinine, uric acid, total cholesterol, and low-density lipoprotein (LDL) values were significantly higher in patients with high blood viscosity. Conclusion Blood viscosity is a physiological variable associated with a number of cardiovascular risk factors in hypertensive patients. Such risk factors are related to renal function and lipid profiles. In high-altitude residents, polycythemia is common, and the consequences of high hematocrit on cardiovascular morbidity in this setting deserve special attention and warrant further research.
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Taco-Vasquez et al. (2019) conducted a cross-sectional in Arterial hypertension (n=132). Whole blood viscosity vs. Normal whole blood viscosity was evaluated on Association between whole blood viscosity and the number of cardiovascular risk factors (p=0.001). Elevated whole blood viscosity was significantly associated with an increased number of cardiovascular risk factors (p=0.001), including higher levels of creatinine, uric acid, total cholesterol, and LDL.
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