LEPR gene Gln223Arg polymorphism and type 2 diabetes mellitus: a meta-analysis of 3,367 subjects

// Yan-Yan Li 1, * , Hui Wang 2, * , Xin-Xing Yang 1 , Jing-Jing Wu 3 , Hong-Yu Geng 1 , Hyun Jun Kim 4 , Zhi-Jian Yang 2 and Lian-Sheng Wang 2 1 Department of Gerontology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China 2 Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China 3 Department of Nephrology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China 4 Department of Physiology, University of Cincinnati, Cincinnati, OH 45267, United States of America * These authors have contributed equally to this work Correspondence to: Yan-Yan Li, email: lyynjmu123@126.com Keywords: leptin receptor , Gln223Arg, polymorphism, type 2 diabetes mellitus Received: February 09, 2017 Accepted: May 22, 2017 Published: June 27, 2017 ABSTRACT Background: The Leptin receptor ( LEPR ) Gln223Arg gene polymorphism has been associated with an increased susceptibility to Type 2 diabetes mellitus (T2DM). Results from various studies, however, are inconsistent. Objective and methods: To better elucidate the association of LEPR Gln223Arg gene polymorphism with T2DM in the Chinese population, a meta-analysis of 3,367 subjects from seven independent studies was performed. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (95% CI) were evaluated by the fixed-effects model. Results: A significant relationship between LEPR Gln223Arg gene polymorphism and T2DM in the Chinese population was found under allele (OR: 1.432, 95% CI: 1.211-1.694, P=2.67×10 -5 ), dominant (OR: 1.466, 95% CI: 1.215-1.769, P=6.33×10 -5 ), recessive (OR: 0.539, 95% CI: 0.303-0.960, P=0.036), heterozygous (OR: 0.700, 95% CI: 0.577-0.849, P=3.06×10 -4 ), and homozygous (OR: 0.472, 95% CI: 0.265-0.839, P=0.011) genetic models. Conclusions: LEPR Gln223Arg gene polymorphism was associated with an increased risk of T2DM in the Chinese population. Therefore, Chinese carriers of the G allele of LEPR Gln223Arg gene polymorphism may be more susceptible to T2DM than the general population.