Key result
An 8-week regimen of glecaprevir/pibrentasvir achieved a 100% sustained virologic response rate at 12 weeks post-treatment in HCV treatment-naïve patients with APRI ≤ 1 and no cirrhosis.
Why the study?
Does an 8-week glecaprevir/pibrentasvir regimen improve sustained virologic response in HCV treatment-naïve adults with APRI ≤ 1 and no prior evidence of cirrhosis?
Does an 8-week glecaprevir/pibrentasvir regimen improve sustained virologic response in HCV treatment-naïve adults with APRI ≤ 1 and no prior evidence of cirrhosis?
An 8-week regimen of glecaprevir/pibrentasvir is highly efficacious and well-tolerated in treatment-naïve patients with chronic HCV and no evidence of cirrhosis (APRI ≤ 1).
May support abbreviated G/P therapy in low-risk HCV; hypothesis-generating and should not yet change practice.
INTRODUCTION: The presence or absence of cirrhosis in patients with chronic hepatitis C virus (HCV) infection influences the type and duration of antiviral therapy. Non-invasive markers, like serum aspartate aminotransferase (AST) to platelet ratio index (APRI), may help identify appropriate HCV treatment-naive patients for 8-week treatment with the pangenotypic regimen of glecaprevir/pibrentasvir. METHODS: This single-arm, open-label, international, prospective study (NCT03212521) evaluated the efficacy and safety of 8-week glecaprevir/pibrentasvir regimen in HCV treatment-naïve adults with chronic HCV genotypes 1-6 infection, APRI ≤ 1, and no prior evidence of cirrhosis. The primary and secondary outcomes were sustained virologic response at 12 weeks post-treatment (SVR12) by modified intent-to-treat (mITT) and intent-to-treat (ITT) analyses, respectively. Additional endpoints included virologic failures, treatment adherence, and genotype-specific SVR12 rates. RESULTS: Among the 230 patients enrolled, most were less than 65 years old (90%); 37% and 43% had a history of injection drug use or psychiatric disorders, respectively. SVR12 rates were 100% (222/222; 95% CI 98.3-100%) and 96.5% (222/230; 95% CI 94.2-98.9%) by mITT and ITT analyses, respectively. There were no virologic failures. ITT SVR12 rates were greater than 94% for all HCV genotypes. In patients with available data, treatment adherence was 99% (202/204). There were no grade 3 or higher laboratory abnormalities in alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin, and low rates of serious adverse events (2%). CONCLUSIONS: Glecaprevir/pibrentasvir was highly efficacious and well tolerated in HCV treatment-naïve patients with APRI ≤ 1 and no prior evidence of cirrhosis. TRIAL REGISTRATION: ClinicalTrials.gov number, NCT03212521. FUNDING: AbbVie. Plain language summary available for this article.
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Fontana et al. (2019) studied Chronic hepatitis C virus (HCV) infection (n=230). Glecaprevir/Pibrentasvir was evaluated on Sustained virologic response at 12 weeks post-treatment (SVR12) by modified intent-to-treat (mITT) (95% CI 98.3-100). An 8-week regimen of glecaprevir/pibrentasvir achieved a 100% sustained virologic response rate at 12 weeks post-treatment in HCV treatment-naïve patients with APRI ≤ 1 and no cirrhosis.