Is Proteinuria Reduction by Angiotensin-Converting Enzyme Inhibition Enough to Prove Its Role in Renal Protection in IgA Nephropathy?

IgA nephropathy (IgAN) is the most common biopsy-proven type of glomerulonephritis globally, including children ([1][1]). In the United States alone, it is estimated that as many as 30% of children with IgAN are likely to progress to ESRD ([2][2]). Most pediatric studies that deal with treatment,