WNT5A is epigenetically silenced in hematologic malignancies and inhibits leukemia cell growth as a tumor suppressor

To the editor: Aberrant activation of the Wnt/β-catenin signaling pathway is a hallmark of cancers.[1][1],[2][2] A recent Blood report showed the down-regulation of multiple Wnt-signaling inhibitors including SFRPs, WIF1 , DKK3 , and DACT1 in acute lymphoblastic leukemia (ALL) cell lines and