Sister Mary Joseph's Nodule

Letters1 March 1998Sister Mary Joseph's NoduleVicente Giner Galvan, MDVicente Giner Galvan, MDHospital Clinic i Provincial; Barcelona, SpainAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-5-199803010-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Sister Mary Joseph's nodule has traditionally been considered a sign of ominous prognosis (survival of 10 months on average) and suggests therapeutic abstention [1]. We conducted a MEDLINE search of papers published from 1966 to January 1997 to evaluate the evidence for this belief.It seems necessary to obtain a histopathologic diagnosis because most umbilical tumors are primary [2]. Fine-needle aspiration biopsy has been established as an adequate method for early and easy diagnosis [3]. A total of 407 reports of Sister Mary Joseph's nodules have been published. The most common origins are gastrointestinal (52%), gynecologic (28%), ...References1. Clements AB. Metastatic carcinoma of umbilicus. JAMA. 1952; 150:556-9. Google Scholar2. Barrow MV. Metastatic tumors of the umbilicus. J Chronic Dis. 1966; 19:1113-7. Google Scholar3. Schneider V, Smyczek B. Sister Mary Joseph's nodule. Diagnosis of umbilical metastases by fine needle aspiration. Acta Cytol. 1990; 34:555-8. Google Scholar4. Majmudar B, Wiskind AK, Croft BN, Dudley AG. The Sister (Mary) Joseph nodule: its significance in gynecology. Gynecol Oncol. 1991; 40:152-9. Google Scholar5. Srinivasan R. Metastatic cutaneous and subcutaneous deposits from internal carcinoma. An analysis of cases diagnosed by fine needle aspiration. Acta Cytol. 1993; 37:894-8. 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