Survey on Substrate Specificity with Regard to ATP Analogs of Aminoacyl-tRNA Synthetases fromE. coliand from Baker’s yeast. Correlation to Synthetase Families

The substrate specificity of twenty aminoacyl-tRNA synthetases from E. coli and thirteen enzymes from baker's yeast with regard to eight ATP analogs is investigated for a comparison of the active-site topography. The enzymes are arranged in a scheme of possible "enzyme families" and compared to earlier schemes.