New talaromydien A (1) and talaroisocoumarin A (2), together with nine known compounds (3 − 11), were isolated from a culture of the marine-derived Talaromyces sp. ZZ1616 in potato dextrose broth medium. Structures of the new compounds were elucidated based on their HRESIMS data, NMR spectroscopic analyses, the modified Mosher′s method, ECD, 13C NMR and optical rotation calculations. Talaroisocoumarin A showed antimicrobial activities with MIC values of 36.0 μg/mL against methicillin-resistant Staphylococcus aureus, 32.0 μg/mL against Escherichia coli, and 26.0 μg/mL against Candida albicans.
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