December 20, 2018Annals of the Rheumatic DiseasesOpen Access

Low aspirin use and high prevalence of pre-eclampsia risk factors among pregnant women in a multinational SLE inception cohort

Q: What is the clinical evidence from this study?

Study design: Letter. Population: Systemic lupus erythematosus (SLE) in pregnancy (n=300). Intervention: Presence of >=1 traditional pre-eclampsia risk factor vs. Absence of traditional pre-eclampsia risk factors. Primary outcome: Aspirin use during pregnancy.

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Key result

In a multinational cohort of 475 SLE pregnancies, aspirin was used in only 25% of cases, and its use did not differ between pregnancies with or without traditional pre-eclampsia risk factors.

Authors

AMArielle MendelMcGill University Health Centre SBSasha BernatskyMcGill University Health Centre JHJohn G. HanlyDalhousie University

Discussion

Member takes

Implication

Aspirin underuse in SLE pregnancies may reflect missed opportunities; prospective trials needed to test risk-stratified prophylaxis.

PICO

Population

300 women aged 18-45 with systemic lupus erythematosus, accounting for 475 pregnancies, evaluated for aspirin use and pre-eclampsia risk factors in a multinational inception cohort.

Exposure / Comparator

Presence of >=1 traditional pre-eclampsia risk factor vs Absence of traditional pre-eclampsia risk factors

Primary Outcome

Aspirin use during pregnancy

Main Result

Absolute Event Rate: 25% vs 26%

Limitations

Lack of data on gestational age and pregnancy outcomes.
Aspirin could have been introduced at or following the study visit when the pregnancy was documented.

Cite This Study

Mendel et al. (2018) conducted a letter in Systemic lupus erythematosus (SLE) in pregnancy (n=300). Presence of >=1 traditional pre-eclampsia risk factor vs. Absence of traditional pre-eclampsia risk factors was evaluated on Aspirin use during pregnancy. In a multinational cohort of 475 SLE pregnancies, aspirin was used in only 25% of cases, and its use did not differ between pregnancies with or without traditional pre-eclampsia risk factors.

synapsesocial.com/papers/6ab62f92a698145f830e4a3c https://doi.org/10.1136/annrheumdis-2018-214434

Topics

Dual antiplatelet therapy

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Low aspirin use and high prevalence of pre-eclampsia risk factors among pregnant women in a multinational SLE inception cohort

Discussion

Member takes

Implication

PICO

Main Result

Limitations

Cite This Study

Topics

Low aspirin use and high prevalence of pre-eclampsia risk factors among pregnant women in a multinational SLE inception cohort

Discussion

Member takes

Implication

PICO

Main Result

Limitations

Cite This Study

Also Consider

Topics

Also Consider