Key result
Specific KLK3b alleles are linked to ~70% higher rates of end-stage renal disease.
Why the study?
Kinins affect cardiovascular and renal function and may be involved in hypertension and renal failure pathogenesis, but the role of plasma kallikrein gene KLK3 in ESRD susceptibility is unclear.
Are human plasma kallikrein gene (KLK3) polymorphisms associated with susceptibility to end-stage renal disease in African Americans?
Population
142 African American sibling pairs concordant for ESRD from 121 families
Comparison
KLK3 gene polymorphisms in ESRD patients vs race-matched controls without renal disease
Design
Genetic association and linkage analysis study
Authors
Loading...
KLK3 polymorphisms may link to ESRD susceptibility; leaves open causal role in hypertension and need for validation.
Case-Control (n=488)
Are human plasma kallikrein gene (KLK3) polymorphisms associated with susceptibility to end-stage renal disease in African Americans?
Absolute Event Rate: 11.2% vs 6.6%
p-value: p=0.0041
Polymorphisms in the human plasma kallikrein gene (KLK3b alleles 7 and 9) are associated with end-stage renal disease susceptibility in African Americans, suggesting a potential genetic role in ESRD pathogenesis.
Yu et al. (1998) conducted a case-control in End-stage renal disease (ESRD) (n=488). KLK3 gene polymorphisms (KLK3b alleles 7 and 9) vs. Race-matched controls without renal disease was evaluated on Association of KLK3b alleles with ESRD (p=0.0041). KLK3b alleles 7 and 9 were significantly associated with end-stage renal disease, present in 11.2% and 10.8% of probands versus 6.6% and 6.6% of controls (P=0.0041 and P=0.0016, respectively).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: