Possible Therapeutic Effect of Ghrelin and exosomes derived from Mesenchymal stem cells on induced chronic pancreatitis of adult albino rats (Histological and Immunohistochemical Study)

Q: What is the clinical evidence from this study?

Study design: RCT. Population: chronic pancreatitis (n=62). Intervention: ghrelin and MSCs derived exosomes vs. control group and affected group. Primary outcome: histological and immunohistochemical changes.

Q: What does this research mean for the field?

Ghrelin and mesenchymal stem cell-derived exosomes attenuate histological damage and reduce markers of inflammation and fibrosis in experimental chronic pancreatitis. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Walaa Mohamed Samy; Mohammed Khalil Yousef; Nahla El-Eraky El-Azab; Nessrein Salem

doi:10.21608/bmfj.2022.114454.1524

June 6, 2022Benha Medical JournalOpen Access

Possible Therapeutic Effect of Ghrelin and exosomes derived from Mesenchymal stem cells on induced chronic pancreatitis of adult albino rats (Histological and Immunohistochemical Study)

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Key result

Ghrelin and MSC-derived exosomes attenuate histological and immunohistochemical damage in experimental chronic pancreatitis.

n=62

Why the study?

Chronic pancreatitis is characterized by irreversible pancreatic damage and the potential therapeutic effects of ghrelin and MSC-derived exosomes require evaluation.

Does treatment with ghrelin and/or MSC-derived exosomes improve histological and immunohistochemical markers in a rat model of induced chronic pancreatitis?

Study Design

Type

RCT (n=62)

Randomization

randomly divided

Structured PICO

Does treatment with ghrelin and/or MSC-derived exosomes improve histological and immunohistochemical markers in a rat model of induced chronic pancreatitis?

P

Population

62 adult male albino rats with induced chronic pancreatitis.

I

Intervention

Ghrelin, mesenchymal stem cell (MSC) derived exosomes, or a combination of both

C

Comparator

Healthy control group, untreated affected group, and recovery group

O

Outcome

Histological and immunohistochemical changes in pancreatic specimens (including collagen fibers deposition, iNOS, and CD8 immunostaining)surrogate

Ghrelin and MSC-derived exosomes demonstrate potential therapeutic effects in ameliorating histological damage in a rat model of chronic pancreatitis.

Implication

May benefit experimental CP in rats; leaves open any human therapeutic role pending clinical studies.

Discussion

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Cite This Study

Samy et al. (2022) conducted an RCT in chronic pancreatitis (n=62). ghrelin and MSCs derived exosomes vs. control group and affected group was evaluated on histological and immunohistochemical changes. Ghrelin and MSC-derived exosomes improved histological microscopic changes in adult albino rats with induced chronic pancreatitis.

synapsesocial.com/papers/6ab6320c008d5ec36e73909b https://doi.org/10.21608/bmfj.2022.114454.1524

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Possible Therapeutic Effect of Ghrelin and exosomes derived from Mesenchymal stem cells on induced chronic pancreatitis of adult albino rats (Histological and Immunohistochemical Study)

Study Design

Structured PICO

Implication

Discussion

Cite This Study

Possible Therapeutic Effect of Ghrelin and exosomes derived from Mesenchymal stem cells on induced chronic pancreatitis of adult albino rats (Histological and Immunohistochemical Study)

Study Design

Structured PICO

Implication

Discussion

Cite This Study

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