PURPOSE: An enhanced version of the ProFit fitting tool was developed and validated to improve the quantification of two-dimensional JRPESS spectroscopic data. METHODS: The proposed enhancements were achieved by flexible organization of prior knowledge, configurations for different situations, the inclusion of measured macromolecular baseline contribution, additional baseline splines and a model-free lineshape based on self-deconvolution. The new software was tested and tuned on simulated data and subsequently applied to in vivo intrasubject and intersubject data. RESULTS: Fit results of simulated and acquired spectra show good overall quality suggesting the potential reliable detection of up to 18 metabolites on a 3T system yielding Cramer-Lower-Bounds below 20%. CONCLUSION: The proposed enhanced version of ProFit together with two-dimensional J-resolved spectroscopy offers the opportunity to reliably detect a wide selection of important brain metabolites on 3T.
No takes yet. Share an insight, caveat, or question.
Fuchs et al. (2013) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: