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The distribution of bromide has been used to measure total body chloride in 50 infants and children. Total chloride has been found to follow the differential growth equation. An index of extracellular water has been obtained and followed with the progress of age. It has been found that infants in early life have 40% more chloride per unit weight than adults. Total chloride/kg. shows a rapid proportionate decrease during the first year of life.
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Donald B. Cheek (1954) studied this question.
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