Key result
Novel IL3/IgH fusion links cutaneous B-lymphoblastic lymphoma to hypereosinophilia and Loeffler endocarditis.
Why the study?
Hypereosinophilia is a rare phenomenon associated with childhood malignancy, predominantly acute lymphoblastic leukaemia, with unclear causation mechanisms.
Case Report (n=1)
This case report highlights a rare presentation of Loeffler endocarditis and hypereosinophilia preceding cutaneous B-lymphoblastic lymphoma with IL3/IgH translocation.
Alerts clinicians to lymphoma risk in pediatric IL3-driven hypereosinophilia; leaves open targeted therapy trials.
Hypereosinophilia is a rare phenomenon associated with childhood malignancy, predominantly acute lymphoblastic leukaemia. Causation is unclear and likely to have multiple mechanisms. We report a six year old boy presenting with hypereosinophilia and associated Loeffler endocarditis. Three months following his initial hypereosinophilia he developed cutaneous B-lymphoblastic lymphoma. Re-analysis of apparently uninvolved bone marrow, taken at initial presentation, revealed a single, previously unidentified, t(5;14)(q31;q32) positive cell. Using fluorescent in situ hybridisation, we demonstrate IL3/IgH@ fusion in cutaneous lymphoma cells. Our case confirms the association of hypereosinophilia and B-lymphoblastic lymphoma and strengthens the association between IL3 hypersecretion and hypereosinophilia.
No takes yet. Share an insight, caveat, or question.
Bomken et al. (2014) conducted a case report in Cutaneous B-lymphoblastic lymphoma with hypereosinophilia and Loeffler endocarditis (n=1). IL3/IgH translocation and hypereosinophilia was evaluated. A 6-year-old boy with hypereosinophilia and Loeffler endocarditis developed cutaneous B-lymphoblastic lymphoma with an IL3/IgH fusion, confirming the association between IL3 hypersecretion and hypereosinophilia.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: