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July 1, 2008Medicinal Chemistry

Synthesis, Characterization, and Antimalarial Activity of Novel Schiff-Base-Phenol and Naphthalene-Amine Ligands

Scott E. Harpstrite Silvia D. Collins Ana Oksman Daniel E. Goldberg Vijay Sharma

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Abstract

Emergence of chloroquine (CQ) resistant Plasmodium falciparum strains necessitates discovery of inexpensive antimalarial drugs capable of targeting CQ-resistant strains. Towards this objective, herein we have synthesized and characterized naphthalene-Schiff bases or naphthalene-amine phenols. Among these compounds, 7 demonstrated a significant bioactivity with a half-maximal inhibitory concentration (IC50) of 1.7 μM against CQ-resistant Dd2 strains. Keywords: Naphthalene-amine, Schiff-base phenol, antimalarials, chloroquine-resistance, P. falciparum

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Harpstrite et al. (2008) studied this question.

synapsesocial.com/papers/6ab63bca51280354e0e41d49 https://doi.org/10.2174/157340608784872280

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