Key result
Fasting, diabetes, and dexamethasone decreased serum ALS levels in rats, with discrepancies between hepatic expression and serum levels suggesting complex post-transcriptional regulation.
The discrepancies between hepatic mRNA expression and serum ALS levels in fasting and diabetes suggest that translational or post-translational events are critical in regulating the acid-labile subunit.
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Caution against clinical extrapolation from rodent ALS data; leaves open post-transcriptional regulation in metabolic stress.
J. Dai (1994) studied this question. Fasting, streptozotocin-diabetes, insulin, and dexamethasone vs. Untreated/baseline state was evaluated on Regulation of ALS expression and serum ALS levels. Fasting, diabetes, and dexamethasone decreased serum ALS levels in rats, with discrepancies between hepatic expression and serum levels suggesting complex post-transcriptional regulation.