Key result
Antidiabetic and antihypertensive regimens linked to drug-related problems in ~91% of diabetic hypertensive patients.
Why the study?
Type 2 diabetes patients with hypertension are at increased risk for drug-related problems due to multiple medications and comorbidities, but studies in this population are lacking.
Cross-Sectional (n=200)
No
Answers are grounded in this paper and cite their sources.
A high prevalence of drug-related problems exists among T2DM patients with hypertension, highlighting the need for early identification and management, particularly in those with polypharmacy, renal impairment, or cardiovascular disease.
BACKGROUND: Type 2 diabetes (T2DM) patients with hypertension are at increased risk for experiencing drug-related problems (DRPs) since they often receive multiple medications and have multiple comorbidities. To date, there is a lack of studies conducted in T2DM patients with hypertension. This study aims to analyze the DRPs and identify factors affecting the DRPs in this patient population. METHOD: This retrospective study involved T2DM patients with hypertension and was conducted at a tertiary hospital in Malaysia from January 2009 to December 2011. The assessment of DRPs was based on the Pharmaceutical Network Care Europe (PCNE) tool version 5.01. RESULTS: Two hundred patients with a total of 387 DRPs were identified. Among these patients, 90.5% had at least one DRP, averaging 1.9 ± 1.2 problems per patient. The most common DRPs encountered were insufficient awareness of health and diseases (26%), drug choice problems (23%), dosing problems (16%) and drug interactions (16%). The most implicated drugs were aspirin, clopidogrel, simvastatin, amlodipine and metformin. The six domains of DRPs found to have statistically significant associations were renal impairment, polypharmacy, cardiovascular disease, elderly status, and duration of hospital stay. CONCLUSIONS: Early identification of the types and patterns of DRPs and the factors associated to them may enhance the prevention and management of DRPs in T2DM patients with hypertension.
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Huri et al. (2013) conducted a cross-sectional in Type 2 diabetes with hypertension (n=200). Antidiabetic and antihypertensive medications was evaluated on Proportion of patients with at least one drug-related problem (DRP). Antidiabetic and antihypertensive medication use in patients with type 2 diabetes and hypertension was associated with at least one drug-related problem in 90.5% of patients, averaging 1.9 problems per patient.
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