Treatment of Malaria — A Continuing Challenge

Twenty years ago, malaria was a neglected disease that was responsible for at least 1 million deaths per year; this high mortality was due in part to reliance on chloroquine, a failing drug, for treatment.1 Since then, there has been substantial progress in malaria control, and the number of deaths from malaria has been reduced by about one third. However, the World Health Organization (WHO) estimates that in 2012, malaria caused 627,000 deaths (estimated range, 473,000 to 789,000),2 so there is still much more to be done. An important contributor to recent success in malaria control has been the widespread . . .