Chiral Recognition of α‐Amino Acid Derivatives with a Homooxacalix[3]arene: Construction of a Pseudo‐C2‐Symmetrical Compound from a C3‐Symmetrical Macrocycle

The shoe fits! The association constants for the complexes formed from the chiral host compound (–)-anti-1MeBu2 [shown in Eq. (a)] and chiral alkylammonium ions such as L-phenylalanine ethyl ester are up to 6.7 times greater than those with the (+) isomer of the host. anti-1MeBu2 is prepared in two steps from the homoox-acalix[3]arene 1H3 [Eq.(a)].