An improved process to N‐demethylate opiate alkaloids utilising a solution of the ferrous porphyrin, tetrasodium 5,10,15,20‐tetra(4‐sulfophenyl)porphyrinatoiron(II) [=Fe(II)‐TPPS (8)], in acetate buffer is described. This method provided the corresponding N‐demethylated opiates in good yield with high reproducibility.
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Kok et al. (2009) studied this question.
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