IARC Perspective on Lung Cancer Screening

Luciana Neamţiu; Matthew E.J. Callister; Philip A.J. Crosbie; Stephen Lam; Vivienne Milch; Daniela Mariosa; Xiaoshuang Feng; Roya Dolatkhah; Ali Saeed Al Zahrani; Zhandos Amankulov; Jean‐Luc Bulliard; Wendy A. Cooper; Luis Corrales; Paolo Giorgi Rossi; Rayjean J. Hung; Ella Kazerooni; Mengmeng Li; Peter Mazzone; Rafael Meza; Arn Migowski; Rachael L. Murray; Samantha L. Quaife; Robert C. Rintoul; Witold Rzyman; Wei Jie Seow; Abhishek Shankar; Mahdi Sheikh; Hilary A. Robbins; Mattias Johansson; Harry J. de Koning; Béatrice Secretan

doi:10.1056/nejmsb2608211

Key Points

Synthesize the global evidence evaluating the balance of benefits and harms in lung cancer screening to guide health policy and program implementation.
Reviewed findings from major randomized controlled trials comparing low-dose computed tomography against chest radiography or standard care.
Evaluated core clinical endpoints, including lung cancer mortality reduction, all-cause mortality, false-positive scan rates, and overdiagnosis.
Low-dose computed tomography screening substantially decreases lung cancer mortality in heavy smokers through early detection of localized disease.
Screening benefits are maximized when health systems minimize invasive procedures for benign nodules and embed structured smoking cessation interventions.

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Implication

Evidence review demonstrates reduced lung cancer mortality with low-dose computed tomography screening in high-risk individuals, highlighting the necessity of structured implementation programs.

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Cite This Study

Neamţiu et al. (2026) studied this question.

synapsesocial.com/papers/6ab6903b68a7ce8912ee8838 https://doi.org/10.1056/nejmsb2608211

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IARC Perspective on Lung Cancer Screening

Key Points

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Implication

Discussion

Cite This Study

IARC Perspective on Lung Cancer Screening

Key Points

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Implication

Discussion

Cite This Study

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