Leprosy has been thought the disease of skin and peripheral nervous system because of its characterictic signs and symptoms. However, some patients show the signs of central nervous disturbances such as bulbar palsy, chorea and so on. To analyse the mechanisms of those peculiar diseases, the author investigated the distribution of ParaRosanilin Positive Materials (LPPM) and tissue injuries in the central nervous system histopathologically with the use of periodic acid-carbol pararosanilin stain (Harada method).
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Nobutaka Yamada (1984) studied this question.
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