Balancing import and export in development

From HOX cofactors to HOX “cofactor complexes” During the development of multicellular organisms, the Hox gene family is involved in axial specification of many different structures, ranging from the neural tube to the intestinal tract. Despite the molecular cloning of the first Hox genes in 1984 and finding that they all encode homeodomain-containing transcriptional regula-tors, there is still little known about the mechanisms by which HOX proteins control gene expression and the nature of the downstream target genes that generate the morphological diversity. a the regulatory activity of proteins. the to proteins by in Drosophila the require binding of the to PBC proteins via the is efficient in in the of