Key result
Nondemented carriers of the rs405509 T/T genotype showed an accelerated age-related reduction of cortical thickness in the left parahippocampal gyrus compared with G-allele carriers.
Why the study?
Does the rs405509 T/T genotype affect cortical morphology in nondemented elderly subjects compared to G-allele carriers?
Population
120 nondemented elderly subjects (aged 52-81 years)
Comparison
rs405509 T/T genotype vs rs405509 G-allele carriers
Design
Cohort
Authors
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Hypothesis-generating for genotype-specific cortical aging; leaves open need for replication before any clinical consideration.
Cross-Sectional (n=120)
No
Does the rs405509 T/T genotype affect cortical morphology in nondemented elderly subjects compared to G-allele carriers?
p-value: p=0.007
The APOE promoter polymorphism rs405509 T/T genotype is associated with accelerated age-related cortical thinning in the left parahippocampal gyrus in nondemented elderly individuals.
Chen et al. (2015) conducted a cross-sectional in Nondemented aging (n=120). rs405509 T/T genotype vs. rs405509 G-allele carriers was evaluated on rs405509 genotype × age interaction effect on cortical thickness (p=0.007). Nondemented carriers of the rs405509 T/T genotype showed an accelerated age-related reduction of cortical thickness in the left parahippocampal gyrus compared with G-allele carriers.
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