A simple, efficient, mild and green method has been developed for the synthesis of 3,4-dihydropyrimidin-2-ones employing dodecyl sulfonic acid as an excellent surfactant-type Brønsted acid catalyst in aqueous media at room temperature. The catalyst was shown to be equally effective for the synthesis of 1,5-benzodiazepines under the same reaction condition.
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Sharma et al. (2006) studied this question.
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