Key result
Growth hormone preserves post-MI LVEF alone or with metoprolol in rats, improving function by ~19%.
Why the study?
Beta-adrenoreceptor blockers are important after MI, and evidence suggests growth hormone improves cardiac function post-MI in rats, but combined effects are unclear.
Does growth hormone alone or combined with metoprolol improve cardiac function in rats after myocardial infarction?
RCT (n=77)
randomly assigned
Does growth hormone alone or combined with metoprolol improve cardiac function in rats after myocardial infarction?
Absolute Event Rate: 6.1% vs -12.5%
p-value: p=<0.01
In a rat model of myocardial infarction, treatment with growth hormone alone or combined with metoprolol preserved left ventricular ejection fraction.
Hypothesis-generating for growth hormone post-MI remodeling; leaves open translation to human heart failure therapy.
Background and objective Beta-adrenoreceptor blocking agents are important for the treatment of myocardial infarction (MI). Accumulating evidence also indicates that growth hormone (GH) improves cardiac function after MI in rats. We aimed to investigate the cardiovascular effects of combined treatment in an animal model of MI. Methods MI was induced in rats by ligation of the left coronary artery. Three days after MI, animals were randomly assigned to one of four groups: controls (C) (n-19); GH (n-19) receiving s.c. 2 mg/kg per day rhGH; metoprolol (M) group (n-19) receiving 24 mg/kg per day and combined group (GHM) (n-20) treated with both GH (2 mg/kg per day s.c.) and M (24 mg/kg per day) for 9 days. Transthoracic echocardiography was performed before and after treatment. Results Serum levels of insulin-like growth factor I were significantly elevated in the GH-group but not in the GHM group compared to controls. Left ventricular volumes, cardiac index, systolic blood pressure, were similar in all groups. Percent changes in ejection fraction compared to baseline were; GH (6.1±5.0%) and GHM (6.1±4.2%) vs. C (−12.5±3.0%), P<0.01, M (−7.3±4.2%). The occurrence of aneurysms was not significantly different between the various treatment regimes. Conclusion Treatment with growth hormone alone or in combination with metoprolol preserved left ventricular function after MI.
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Bollano et al. (2001) conducted an RCT in Myocardial infarction (n=77). Growth hormone alone or combined with metoprolol vs. Controls or metoprolol alone was evaluated on Percent changes in ejection fraction compared to baseline (p=<0.01). Growth hormone alone or combined with metoprolol preserved left ventricular ejection fraction after myocardial infarction in rats compared to controls (6.1% vs -12.5%, P<0.01).
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