HARSCHFIELD (1965) has reviewed the literature with reference to immunization against fowl cholera. His only reference to a living vaccine was Pasteur’s attenuated fowl cholera vaccine. Hayden (1914) produced immunity against Pasteurella multocida in rabbits, chickens, and pigeons by injecting an avirulent live P. multocida vaccine. Sinha et al. (1957) found that a living avirulent mouse strain of P. multocida was a better immunizing agent than heat-killed strains. Ose et al. (1963) reported on the use of an avirulent oral live erysipelas vaccine for use in swine; this type vaccine is presently produced commercially. Bain (1963), referring to pasteurellosis in cattle, has suggested that with improved methods of technology, living attenuated vaccines may become the main method of prophylaxsis in the future. Heddleston and Rebers (1968) have reported that active immunity was induced in chickens and turkeys by oral administration of a killed P. multocida vaccine. Bierer and Eleazer (1968)…
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Bierer et al. (1969) studied this question.