Key result
Hydrogel-delivered rhSGK3 improves cardiac function and promotes repair after ischemia/reperfusion injury in mice.
Why the study?
Current therapies for myocardial infarction fail to promote cardiac regeneration, and novel strategies to enhance myocardial repair are needed.
Does intramyocardial injection of rhSGK3-hydrogel improve cardiac repair in a mouse model of ischemia/reperfusion injury?
Population
Neonatal mouse cardiomyocytes in vitro and myocardial ischemia/reperfusion mouse model in vivo
Comparison
Intramyocardial injection of rhSGK3-hydrogel vs control
Design
Preclinical experimental study
Follow-up
28 days post-I/R
Authors
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Hypothesis-generating for rhSGK3-hydrogel in post-infarct repair; leaves open translation to human ischemia/reperfusion injury.
Does intramyocardial injection of rhSGK3-hydrogel improve cardiac repair in a mouse model of ischemia/reperfusion injury?
Local delivery of rhSGK3 via a thermosensitive hydrogel promotes cardiac repair after ischemia/reperfusion injury through HIF-1α/HK2-mediated glycolytic reprogramming.
Wei et al. (2026) studied Myocardial ischemia/reperfusion injury. Recombinant human SGK3 (rhSGK3) protein hydrogel was evaluated on Cardiac function, cardiomyocyte proliferation, apoptosis, and fibrotic scar formation. Local delivery of rhSGK3 via a thermosensitive hydrogel significantly improved cardiac function and promoted cardiac repair after ischemia/reperfusion injury in a mouse model.
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