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June 1, 1977Journal of Medicinal Chemistry

5-Aryl-1,5-dihydro-2H-1,4-benzodiazepin-2-one derivatives as antianxiety agents

Masaru Ogata Hiroshi Matsumoto Katsumi Hirose

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Abstract

A new series of 7-chloro- and 7-nitro-5-methoxy-5-phenyl-1,5-dihydro-2H-1,4-benzodiazepin-2-ones (7a, c--e) was synthesized and found to have potent antipentylenetetrazole activity. These compounds were also employed as intermediates in the synthesis of 3-substituted 1,3-dihydro-1,4-benzodiazepin-2-ones (8f--v).

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Ogata et al. (1977) studied this question.

synapsesocial.com/papers/6ab71afee5cc1b7921e41f0b https://doi.org/10.1021/jm00216a008

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