D‐dimer Triage for COVID‐19

C oagulopathy and elevated D-dimer levels were rec- ognized as prognostic factors early in Wuhan, China, as accompanying more severe COVID-19 patient cases.We sought to determine the accuracy of normal versus elevated D-dimer blood levels at presentation, on day 1, and on day 3 for predicting 28-day survival in a large cohort of consecutive PCR-proven COVID-19 patients to help with patient triage, reassurance, and follow-up management.This is an observational study of a cohort of consecutive patients presenting to Affiliated Hospital of Jianghan University, Wuhan, from January 10 through February 28, 2020.Before data collection, we obtained patients' consent and ethical approval from the Medical Ethics Committee of Jianghan University Affiliated Hospital and China-Japan Friendship Hospital (WHSHIRB-K-2020015).D-dimer levels (Nanopia immunoturbidimetric assay, Sekisui Medical; abnormal > 1.0 mg/L) were measured at day 1 presentation in nearly all patients and again on day 3 and afterward in many.Patients without day 1 D-dimer levels were excluded from the analysis.