High-Dose-UVA1 irradiation has recently been found to be a new, prompt-acting and highly effective phototherapeutic approach to the treatment of patients with acute exacerbation of atopic dermatitis. This therapeutic efficacy was demonstrated by a marked improvement of clinical symptoms as well as of laboratory parameters, which were found to reflect disease activity in atopic dermatitis. Investigation of the photoimmunological mechanisms responsible for the therapeutic effectiveness of this modality indicates that eosinophils and epidermal Langerhans cells may be targets for High-Dose-UVA1.
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A 1992 study studied this question.