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Studies with the jackbean lectin, concanavalin A, were undertaken to clarify the relationship between tissue factor and the cell membrane of cultured fibroblasts. Concanavalin A blocks the coagulant activity of tissue factor of cultured human skin fibroblasts and also rabbit brain. The inhibitory effect, which is dose-dependent and reversed by alpha-methyl-D-mannopyranoside, cannot be explained by an effect on other reactants necessary for clot formation. These results support the contention that tissue factor is located on the cell surface. Since concanavalin A does not affect adhesion-related phenomena in cultured cells, these results also suggest that tissue factor produced by trypsinized fibroblasts is a consequence rather than the cause of cell adhesion and that tissue factor is not synonymous with the adhesive site on the cell surface.
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Zacharski et al. (1974) studied this question.
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