Key result
Resection of cardiac histiocytoid hemangioma dramatically resolves severe peripheral eosinophilia.
Why the study?
Histiocytoid hemangioma of the heart is a rare tumor that may be mistaken clinically and pathologically, with unclear association to peripheral eosinophilia.
Case Report (n=1)
Histiocytoid hemangioma of the heart can present with peripheral eosinophilia that resolves upon tumor resection, and may mimic myxoma clinically.
Cardiac histiocytoid hemangioma may link to reversible eosinophilia; leaves open causal role and need for targeted evaluation in unexplained cases.
A histiocytoid hemangioma of the heart is reported, which was found incidentally in a man with unusually high eosinophilia. The eosinophilia subsided dramatically following removal of the tumor. The "histiocytoid" or the "epithelioid" appearance of the tumor cells and the presence of vacuolated cells were the characteristic microscopic features. The endothelial origin of this tumor was verified by positive immunostaining for factor VIII-related antigen and ultrastructural demonstration of intracytoplasmic lumen formation, abundant cytoplasmic filaments, pinocytotic vesicles, and prominent basal lamina. The presence of mitotic activity, cellular pleomorphism, and tumor necrosis raised the possibility of its malignant potential. The occurrence of this tumor in the heart may be mistaken for a myxoma clinically and a metastatic carcinoma pathologically.
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Kuo et al. (1985) conducted a case report in Histiocytoid hemangioma of the heart with peripheral eosinophilia (n=1). Tumor removal was evaluated on Resolution of eosinophilia. Removal of a histiocytoid hemangioma of the heart led to dramatic subsidence of unusually high peripheral eosinophilia in a male patient.
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